Research on quality of life has gained attention globally. There is however dearth of this research in Nigeria. The present study therefore investigated the influence of perceived social support, life satisfaction, and functional impairment on quality of life among retirees in Ido Osi LGA in Ekiti State, Nigeria. The disengagement theory of quality of life served as the framework for this study. Using descriptive survey research design, 102 participants were conveniently selected from Ido Osi LGA in Ekiti State (mean age = 63.34. SD = 7.39) Validated scales were used for data collection. Pearson product moment correlation, t-test and multiple regression analysis were conducted on two hypotheses in the study. Result indicated that there is significant negative relationship between functional impairment and quality of life; r = -.29; P<.01. Life satisfaction also has a significant relationship with quality of life: r = .347; P < .01. Perceived social support has a significant positive relationship with quality of life: r = .228; P < .01. The result also revealed that perceived social support, functional impairment and life satisfaction significantly and jointly predicted Quality of life among retirees (R=.401; R2 = .161, F (3,232) = 14.840, p<.01). Furthermore, the findings of this study showed that reveals that socio-demographic variables had no significant joint or independent influence on quality of life among retirees. (R= 1.46 R2 = .161, F (6,231) = .841, p>.05); this implies that age, religion, marital status, ethnicity, educational qualification and gender does not jointly or independently predict quality of life among retirees. In conclusion perceived social support, life satisfaction, and functional impairment had significant influence on quality of life. The authorities of Ido Osi LGA in Ekiti State should give due consideration to the presents finding in the management of quality-of-life constructs/issues raised in this study.