This article examines the cultural interactions between the kingdom of Funan and the Indian subcontinent through an interdisciplinary analysis of the Óc Eo material civilization in the Mekong Delta. Drawing upon archaeological excavations, remote sensing and GIS-based landscape reconstruction, archaeobotanical evidence, and stylistic comparisons of religious architecture and iconography, the study demonstrates that Óc Eo was a major hub within transregional exchange networks linking Southeast Asia, South Asia, and the wider Indian Ocean world. Recent analyses of microremains found on grinding tools, including turmeric, ginger, and other South Asian spices, reveal culinary and botanical exchanges that complement long-established evidence of Hindu–Buddhist religious transmission. Geo-archaeological studies further indicate a sophisticated canal-based urban landscape that facilitated inland–maritime connectivity and supported Funan’s economic prosperity. Architectural remains, Sanskrit inscriptions, metallurgical signatures, and sculptural styles demonstrate strong correlations with Gupta-period India, particularly from the 4th to 6th centuries CE. By synthesizing new data from multiple scientific fields with classical historical sources, this study re-evaluates the mechanisms through which Indian cultural, technological, and ideological elements were localized and transformed within the Óc Eo cultural sphere. The findings provide a deeper understanding of early cultural globalization and the development of complex societies in mainland Southeast Asia.