Traditional medicine has long been an integral part of Sri Lankan healthcare, and its role in managing epidemics is of particular interest due to its historical and cultural significance. This research seeks to shed light on the traditional disinfection methods and rituals employed by traditional healers and communities during epidemic crises, while also exploring the sociocultural factors that influence these practices. Disinfection is unique among the strategies adopted to control the disease in an epidemic situation. This makes it possible to control the spread of pathogens. In Sinhala medicine, Sri Lanka’s traditional medicine, are traditional disinfecting techniques employed for the prevention and control of epidemic diseases? If so, what are the disinfection practices used? Based on these research questions, this research was conducted. The aim of this research is to study the traditional disinfection practices recommended by Sinhala medicine to protect against the epidemic disease as well as to control the spread of the disease during the epidemic season. As an exploratory research using the mixed method based on qualitative data and quantitative data, the Pragmatist paradigm was utilized by the researcher with a phenomenological research design. There, the study area covering the 03 districts of Colombo, Monaragala, and Anuradhapura was selected purposefully and 2 samples were selected from the study area as a sample of 15 traditional medicine practitioners and a sample of 60 elderly people over 50 years of age. Traditional medicine in the country has long been a repository of knowledge that reflects an intricate understanding of the environment, disease ecology, and societal well-being. During epidemics, such practices gain prominence, not only as therapeutic interventions but also as community-driven preventive measures. The study revealed many traditional disinfection methods used by the Sri Lankan community during the epidemic. Many practices such as the use of water mixed with turmeric and lime, steam capture, fumigation etc. could be identified here. The special thing here is that only natural ingredients obtained from the surrounding environment are used for these methods. It could be concluded that this disinfection process is carried out in an environmentally friendly and humane manner.